AGE AT ONSET OF PSYCHOSIS IN PATIENTS WITH SCHIZOPHRE- NIA: EVIDENCE FOR A SEX-DEPENDENT INTERACTION BETWEEN BDNF VAL66MET GENOTYPE AND CANNABIS USE
2 de fevereiro de 20111min21
Jeroen Decoster, Jim van Os, Gunter Kenis, Cécile Henquet, Joseph Peuskens, Marc De Hert, Ruud van Winkel
Background: Discovering modifiable predictors for age at onset may help to identify predictors of transition to psychosis in the ‘at- risk mental state’. Previous studies inconsistently reported main effects of sex, BDNF Val66Met and cannabis, suggesting more complex models may be required. A sex-specific model of gene- environment interaction between BDNF Val66Met and cannabis use, affecting age at onset of psychosis, was hypothesized.
